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| Registros recuperados: 98.244 | |
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| Galbiatti,A.L.S.; Ruiz,M.T.; Biselli-Chicote,P.M.; Raposo,L.S.; Maniglia,J.V.; Pavarino-Bertelli,E.C.; Goloni-Bertollo,E.M.. |
| The functional effect of the A>G transition at position 2756 on the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase), involved in folate metabolism, may be a risk factor for head and neck squamous cell carcinoma (HNSCC). The frequency of MTR A2756G (rs1805087) polymorphism was compared between HNSCC patients and individuals without history of neoplasias. The association of this polymorphism with clinical histopathological parameters was evaluated. A total of 705 individuals were included in the study. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype the polymorphism. For statistical analysis, the chi-square test (univariate analysis) was used for comparisons between groups and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Head and neck cancer; Polymorphism; Folate metabolism; MTR gene. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500005 |
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| Erig,Alan Cristiano; De Rossi,Andrea; Fortes,Gerson Renan de Luces. |
| O presente trabalho avaliou o efeito de diferentes níveis de BAP (0; 2; 4; 6; 8 e 10miM) e de AIB (0; 0,5 e 1miM) na multiplicação in vitro da amoreira-preta cv. Tupy. O meio utilizado foi o MS suplementado com 100mg.<IMG SRC="http:/img/fbpe/cr/v32n5/11864s1.gif">-1 de mio-inositol, 30g.<IMG SRC="http:/img/fbpe/cr/v32n5/11864s1.gif">-1 de sacarose e 6g.<IMG SRC="http:/img/fbpe/cr/v32n5/11864s1.gif">-1 de ágar. Após a inoculação, as culturas foram mantidas em sala de cultura com 16 horas de fotoperíodo, temperatura de 25 ± 2ºC e radiação de 25µmoles.m-2.s-1. O número de gemas e o número de brotações foram avaliados com intervalo semanal, num total de quatro avaliações, e, na última avaliação, considerou-se a altura da brotação, bem como... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Reguladores de crescimento; Micropropagação; Cultura de tecidos. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782002000500005 |
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| HOU,CHUN; MIAO,YONG; JI,HANG; WANG,SUSHENG; LIANG,GANG; ZHANG,ZHIHUA; HONG,WEIJIN. |
| ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MMP2; MMP9; 6-Gingerol; Hair growth. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602707 |
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| ALMEIDA,MACIA C.S. DE; SOUZA,LUCIANA G.S.; FERREIRA,DANIELE A.; PINTO,FRANCISCO C.L.; OLIVEIRA,DÉBORA R. DE; SANTIAGO,GILVANDETE M.P.; MONTE,FRANCISCO J.Q.; BRAZ-FILHO,RAIMUNDO; LEMOS,TELMA L.G. DE. |
| ABSTRACT A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complete assignment of the 1H and 13C NMR spectra. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bauhinia pentandra; Fabaceae; Cyanoglucoside; Lactones; RMN.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100065 |
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| Dieter,Cristine; Assmann,Taís Silveira; Lemos,Natália Emerim; Massignam,Eloísa Toscan; Souza,Bianca Marmontel de; Bauer,Andrea Carla; Crispim,Daisy. |
| Abstract Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS). ROS overproduction is a key contributor to the pathogenesis of diabetic kidney disease (DKD). Thus, UCP2 polymorphisms are candidate risk factors for DKD; however, their associations with this complication are still inconclusive. Here, we describe a case-control study and a meta-analysis conducted to investigate the association between UCP2 -866G/A and Ins/Del polymorphisms and DKD. The case-control study comprised 385 patients with type 1 diabetes mellitus (T1DM): 223 patients without DKD and 162 with DKD. UCP2 -866G/A (rs659366) and Ins/Del polymorphisms were genotyped by real-time PCR and conventional PCR, respectively. For the meta-analysis, a literature search was conducted... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: UCP2; Polymorphisms; Diabetic kidney disease. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400101 |
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| Olaya,María del Pilar; Vergel,Nadezdha Esperanza; López,Jose Luis; Viña,Dolores; Guerrero,Mario Francisco. |
| Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were evaluated. To do this, we used the reserpine model of Parkinson’s disease, an assay of levodopa/carbidopa potentiation, the catalepsy model of haloperidol, and an in vitro assay against monoamine oxidase (MAO) activity. Additionally, lipid peroxidation and protein carbonyl group quantification was performed in mice brain homogenates previously treated with haloperidol. FCS303 inhibited monoamine oxidase B (MAO-B) with an IC50 of 5.46 ± 0.36 µM; however, there was no effect on monoamine oxidase A (MAO-A). The oral... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson’s disease; Monoamine oxidase B; Coumarin; Mice; Reserpine; Levodopa; Carbidopa. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100508 |
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| Sá,Matheus Malta de; Pasqualoto,Kerly Fernanda Mesquita; Rangel-Yagui,Carlota de Oliveira. |
| Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost consuming, theoretical methods such as quantitative structure-property relationships (QSPR) can be useful to predict logBB values. In this study, a 2D-QSPR approach was applied to a set of 28 drugs acting on the CNS, using the logBB property as biological data. The best QSPR model [n = 21, r = 0.94 (r² = 0.88), s = 0.28, and Q² = 0.82] presented three molecular descriptors: calculated n-octanol/water partition coefficient (ClogP), polar surface area (PSA), and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Two-dimensional quantitative structure-property relationships (2D-QSPR); Calculated n-octanol/water partition coefficient (ClogP); Blood-brain barrier; Benzodiazepines. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400016 |
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| Passos Jr.,Geraldo A.S.; Lefranc,Marie-Paule. |
| The human immunoglobulin lambda variable locus (IGLV) is mapped at chromosome 22 band q11.1-q11.2. The 30 functional germline v-lambda genes sequenced untill now have been subgrouped into 10 families (V<FONT FACE="Symbol">l</font>1 to V<FONT FACE="Symbol">l</font>10). The number of V<FONT FACE="Symbol">l</font> genes has been estimated at approximately 70. This locus is formed by three gene clusters (VA, VB and VC) that encompass the variable coding genes (V) responsible for the synthesis of lambda-type Ig light chains, and the J<FONT FACE="Symbol">l</font>-C<FONT FACE="Symbol">l</font> cluster with the joining segments and the constant genes. Recently the entire variable lambda gene locus was... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000400027 |
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| Smol, N.; Huys, R.; Vincx, M.. |
| Sublittoral meiofauna of 24 stations was monitored over 4 years (1984-1987) in and around a dumping site for TiO<sup>2-</sup> acid waste in the Southern Bight of the North Sea off the Dutch coast. The meiofauna was examined quantitatively and qualitatively with special reference to the nematode and the copepod community structure down to species level and to the trophic structure of the nematodes. Biological, sedimentological, geographical parameters and the concentration of several heavy metals were subject to multivariate statistical analysis and classification techniques to evaluate the impact of the TiO<sup>2-</sup> dumping activities. The meiofauna is dominated by nematodes, copepods, gastrotrichs and turbellarians. There is a... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1991 |
URL: http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2890 |
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| Calado,Nicácia Barbosa; Sousa Júnior,Francisco Canindé de; Diniz,Mariana Guimarães; Fernandes,Ana Cristina Santos; Cardoso,Fernando José Ramos; Zaror,Luiz Conrado; Ferreira,Maria Ângela Fernandes; Milan,Eveline Pipolo. |
| In the present study, we determined the frequency of superficial and cutaneous mycoses and their etiologic agents during a 7-year period (2002-2008) in Natal, Brazil. A total of 1,717 specimens of skin, nail, and hair were collected from 1,382 patients with suspected mycoses lesions and were then subjected to direct microscopy and culture. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cutaneous mycoses; Dermatophytes; Fungal infections; Yeasts; Superficial mycoses. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000400008 |
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| Moraes,Ferdinando Roberto Pupo de; Catani,Renato A.. |
| São apresentados dados da variação na concentração de nitrogênio, fósforo, potássio, cálcio e magnésio no fruto do cafeeiro durante a sua formação, bem como das quantidades dos elementos absorvidos pelo fruto e da acumulação de matéria sêca em diversos estágios de seu desenvolvimento. A concentração dos elementos dosados foi sempre maior na flor que em qualquer outro estágio da maturação. O inverso ocorreu com a concentração de matéria sêca, em conseqüência da redução progressiva do teor de água no fruto. A acumulação de matéria sêca no fruto intensificou-se a partir do início do 4.° mês após o florescimento. O mesmo ocorreu com a absorção de nitrogênio, fósforo e potássio. Nôvo incremento na absorção de nitrogênio e potássio e no aumento do pêso sêco foi... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1964 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0006-87051964000100026 |
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| Catani,R. A.; Pelegrino,D.; Bergamin Filho,H.; Glória,N. A. da; Graner,C.A.F.. |
| O presente trabalho relata os dados obtidos sôbre a concentração e a quantidade de macronutritntes, N, P, K, Ca, Mg e S no tronco, ramos, fôlhas e frutos do cafeeiro, Coffea arabica, L, variedade mundo novo [(B. Rodr.) Choussy], aos dez anos de idade e crescendo em solo latossólico da Escola Superior de Agricultura "Luiz de Queiroz", em Piracicaba. São apresentados também os dados obtidos nas mesmas condições, sôbre o pêso de diversas partes (tronco, ramos, fôlhas e frutos) do cafeeiro. |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1965 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0071-12761965000100007 |
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| Catani,R. A.; Arruda,H. C.; Pelegrino,D.; Bergamin F.°,H.. |
| This paper describes the data obtained for the growth of sugar cane, Variety Co 419, and the amount and rate of absorption of nitrogen, phosphorus, potassium, calcium, magnesium, sulfur, and silicon, according to the age of the plant, in the soil and climate conditions of the state of S. Paulo, Brazil. An experiment was installed in the Estação Experimental de Cana de Açúcar "Dr. José Vizioli", at Piracicaba, state of S. Paulo, Brazil, and the soil "tèrra-roxa misturada" presented the following composition: Sand (more than 0,2 mm)........................................................................ 8.40 % Fine sand (from 0,2 to less than 0,02 mm)................................................. 24.90 % Silt (from 0,02 to less than 0,002... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1959 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0071-12761959000100012 |
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| Registros recuperados: 98.244 | |
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